Southwest Surgical Associates
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Guillermo Ponce de Leon, M.D., FACS

Guillermo Ponce de Leon, M.D., FACS

Office Locations

Memorial Hermann
Southwest Clinic

7737 Southwest Fwy
Suite 100
Houston, Texas 77074
Phone: 713.772.1200

Methodist Sugar Land Clinic
16651 Southwest Fwy
Suite 360
Sugar Land, Texas 77479
Phone: 281.491.6200

Memorial Hermann
Sugar Land Clinic

17510 W. Grand Parkway S.
Suite 490
Sugar Land, Texas 77479
Phone: 281.342.8932



Dr. Ponce de Leon is a native of Houston who completed medical school at the University of Texas at Houston. He completed general surgery training at Baylor University Medical Center in Dallas. He is a pioneer in advanced laparoscopic surgery, recently performing the first single incision adrenolectomy in Texas. He also specializes in bariatric surgery, including lap band. Dr. Ponce de Leon is a fluent Spanish speaker and stays active in the Hispanic community. In his spare time he enjoys fishing and spending time with his family.



  • General Surgeon, Southwest Surgical Associates, LLP – July 1998 to present
    • Specialty in General Surgery with expertise in Advanced Laparoscopic Surgery
  • First Assistant in Surgery
    • Medical City – Columbia Hospital, Dallas, Texas., 1997 –June 1998 
  • Emergency Room
    • Columbia Medical Center, Arlington, Texas, 1994 – June 1998
  • Emergency Room
    • EMCARE, Dallas, Texas, 1994 – June 1998
  • General Surgery Internship/Residency
    • Baylor University Medical Center, Dallas, Texas, 1993 – 1998
  • Transitional Internship
    • University of Texas at Houston, School of  Medicine,1992 – 1993
  • Doctor of Medicine
    • University of Texas at Houston, School of Medicine,1988-1992
  • Bachelor of Science, Biology & Chemistry
    • Houston Baptist University, Houston, Texas, 1978 – 1982
  • Clinical Assistant Professor of Surgery (General)
    • The University of Texas Health Science Center at Houston Medical School            
  • Chair of the Department of Surgery
    • Methodist Sugar Land  Hospital, 2005 to present
  • Chairman of the Department of Surgery
    • Sugar Land Surgical Hospital, 2005 to present
  • Chariman of Peri-operative Committee
    • The Methodist Hospital, Sugar Land
  • Awarded for Top Score in Surgical In Training Exam During Internship at Baylor

  • Fellow, American College of Surgeons 
  • American Board of Surgery
  • American Medical Association
  • Texas Medical Association
  • Memorial Hermann Hospital Southwest
  • Memorial Hermann Hospital Sugar Land
  • The Methodist Hospital Sugar Land
  • St. Luke’s Episcopal Hospital Sugar Land
  • Sugar Land Surgical Hospital